J C Monahan Separation (2024)

1. JC Monahan: Breaking My Silence - Boston Magazine

6 apr 2021 · I made two major decisions: I filed for divorce after more than 15 years of marriage and signed off at WCVB, the place that had shaped my career ...
For many years, NBC Boston anchor JC Monahan had a secret—and keeping it nearly cost her everything.

7 apr 2021 · NBC10 Boston's JC Monahan is sharing her struggles with depression and “debilitating” anxiety. Read more on Boston.com.
NBC10 Boston’s JC Monahan is sharing her struggles with depression and “debilitating” anxiety with the hope that opening up about her experiences may help others grappling with mental health issues. In […]

27 sep 2023 · JC Monahan is an Emmy award winning journalist with more than 25 years of experience. She is also an AMS sealed meteorologist. In 2001 JC began ...
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14 dec 2023 · ... separation. The properties of BCs of FUS have ... Monahan Z.; Ryan V. H.; Janke A. M.; Burke ... J. C.; Rouan D.; Spohn T.; Tirard S.; Viso M ...
Formation of liquid condensates plays a critical role in biology via localization of different components or via altered hydrodynamic transport, yet the hydrogen-bonding environment within condensates, pivotal for solvation, has remained elusive. We explore ...

2 aug 2021 · Methods to study liquid separation are being developed (to observe LLPS); we review them below. ... Monahan, Z. et al. Phosphorylation of the ...
Emerging evidence suggests that liquid–liquid phase separation (LLPS) represents a vital and ubiquitous phenomenon underlying the formation of membraneless organelles in eukaryotic cells (also known as biomolecular condensates or droplets). Recent studies have revealed evidences that indicate that LLPS plays a vital role in human health and diseases. In this review, we describe our current understanding of LLPS and summarize its physiological functions. We further describe the role of LLPS in the development of human diseases. Additionally, we review the recently developed methods for studying LLPS. Although LLPS research is in its infancy—but is fast-growing—it is clear that LLPS plays an essential role in the development of pathophysiological conditions. This highlights the need for an overview of the recent advances in the field to translate our current knowledge regarding LLPS into therapeutic discoveries.

20 apr 2021 · Cross-interaction-driven phase separation is the phase separation ... Monahan Z, Ryan VH, Janke AM, Burke KA ... JC, Li CH, Guo YE, Day DS, ...
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Biological phase separation is known to be important for cellular organization, recently extending to a new class of biomolecules that form liquid-like droplets coexisting with the surrounding cellular, or extracellular environment. These droplets are ...

... J.C.; Hannett, N.M.; et al. Transcription Factors Activate Genes through the Phase-Separation Capacity of Their Activation Domains. Cell 2018, 175, 1842 ...
Liquid–liquid phase separation (LLPS) is a biophysical process that mediates the precise and complex spatiotemporal coordination of cellular processes. Proteins and nucleic acids are compartmentalized into micron-scale membrane-less droplets via LLPS. These droplets, termed biomolecular condensates, are highly dynamic, have concentrated components, and perform specific functions. Biomolecular condensates have been observed to organize diverse key biological processes, including gene transcription, signal transduction, DNA damage repair, chromatin organization, and autophagy. The dysregulation of these biological activities owing to aberrant LLPS is important in cardiovascular diseases. This review provides a detailed overview of the regulation and functions of biomolecular condensates, provides a comprehensive depiction of LLPS in several common cardiovascular diseases, and discusses the revolutionary therapeutic perspective of modulating LLPS in cardiovascular diseases and new treatment strategies relevant to LLPS.

T) intermediates and then the subsequent separation of these intermediates into separated triplet excitons on longer timescales. ... Monahan, N. R.; Sun, D.; ...

Ferreon, J. C. et al. Acetylation disfavors tau phase separation. Int. J. Mol. Sci. 19, 1360. (2018). 13. Monahan ...

27 jan 2020 · J. C.. Blancon. ,. H. Tsai. ,. W. Nie. ,. C. C.. Stoumpos. ,. L. Pedesseau. ,. C. Katan. ,. M. Kepenekian. ,. C. M. M.. Soe. ,. K. Appavoo. ,.

1 aug 2018 · BF12 Bobot BFilliâtre J-CSeparation predicates: a taste of separation ... LM10 Leino KRM, Monahan R (2010) Dafny meets the verification benchmarks ...
AbstractFraming is important for specification and verification, especially in programs that mutate data structures with shared data, such as DAGs. Both separation logic and region logic are succes...

... Separation of FUS. by Shannon N. Rhoads. Shannon N. Rhoads. SciProfiles Scilit Preprints.org Google Scholar. , Zachary T. Monahan. Zachary T. Monahan.
Subcellular mislocalization and aggregation of the human FUS protein occurs in neurons of patients with subtypes of amyotrophic lateral sclerosis and frontotemporal dementia. FUS is one of several RNA-binding proteins that can functionally self-associate into distinct liquid-phase droplet structures. It is postulated that aberrant interactions within the dense phase-separated state can potentiate FUS’s transition into solid prion-like aggregates that cause disease. FUS is post-translationally modified at numerous positions, which affect both its localization and aggregation propensity. These modifications may influence FUS-linked pathology and serve as therapeutic targets.